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Lung dose and risk for complication

Project title: Estimation of lung dose and estimation of risk for radiation induced complications after breast and lung cancer treatments

PhD student: Emma Hedin

Supervisors: Anna Bäck, Roumiana Chakarova and Peter Bernhardt

Aim: To improve the estimation of risk for radiation induced complications that is made based on the planned dose. The project focuses on lung tissue complications after breast and lung cancer treatments.

The risk for complication in lung tissue is estimated by calculating values of dose measures that have been found to correlate with response. The dose measures investigated and recommended in QUANTEC [1] is for example mean lung dose (MLD) or lung volume receiving 20 Gy or more (V20). The risk for complication can also be estimated by calculation of Normal Tissue Complication Probability (NTCP) according to some biological model. The NTCP calculation is based on the calculated spatial dose distribution. All dose measures are directly depending on the accuracy of the estimation of dose. This project wants to investigate how the inaccuracies in the estimation of delivered dose affects the estimation of risk of complication.

The work includes dose inaccuracies related to clinical dose calculation algorithms and their impact on risk estimation. Monte Carlo calculations will be used as reference to study the dose distribution in lung according to clinical treatment plans. The work also includes investigation of how the lung dose distribution is affected by the technical tolerances of jaw positioning, especially in the case of adjacent fields of a loco-regional breast cancer treatment. Other factors identified as of interest to the project are breathing motions during dose delivery and CT image collection, respectively, as well as setup errors.

Published dose-response relationships will be studied in terms of how they are affected by dose inaccuracies. A method for handling the effects and thereby improving the accuracy of risk estimation will be developed.

[1] Marks L B, Bentzen S M, Deasy J O et al. (QUANTEC) Radiation dose-volume effects in the lung. Int. J. Radiation Oncology Biol. Phys. 2010, Vol. 76(3), Supplement, pp S70-S76





Page Manager: Johan Spetz|Last update: 12/9/2014

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